RBIO-03. IMPROVING GEMCITABINE-MEDIATED RADIO-SENSITIZATION USING MOLECULARLY TARGETED MENINGIOMA THERAPY

Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: a review.

In the last three decades, gemcitabine has progressed from the status of a laboratory cytotoxic drug to a standard clinical chemotherapeutic agent and a potent radiation sensitizer. In an effort to improve the efficacy of gemcitabine, additional chemotherapeutic agents have been combined with gemcitabine (both with and without radiation) but with toxicity proving to be a major limitation. There...

Molecularly Targeted Therapy: Imatinib and Beyond

Targeted therapy: resistance and re-sensitization.

The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although ta...

Evaluation of gold nanoparticles radio sensitization effect in radiation therapy of cancer: review article

In recent years, the use of gold nanoparticles (GNPs) in radiation therapy has been studied by experimentation and Monte Carlo simulation repeatedly. Although the idea of increasing doses has been raised by high-atomic elements since decades ago, but due to the adaptation of gold nanoparticles with the biological system, scientists have incited more about the various uses of these materials in ...

Imatinib Mesylate: A Molecularly Targeted Therapy for Gastrointestinal Stromal Tumors

Although their overall incidence is uncommon, gastrointestinal stromal tumors (GIST) are the most frequently encountered mesenchymal tumors of the GI tract. Their pathology has been recently defined by the presence of KIT (transmembrane receptor tyrosine kinase). The majority of GISTs have c-kit gain-of-function mutations mainly in exon 11 (highly conserved juxtamembrane region) that eventuates...